Computational Insight into Binding Affinity and Drug-Likeness of Synthesized Schiff Base and Its Transition Metal Complexes
Keywords:
Binding Affinity, Schiff Base, Transition Metal Complexes, Inorganic, Bioinorganic, Optical Materials, Biological Activity, Antimicrobial, Anticancer, Antioxidant, , Structure-Activity, Microbes, Copper, Nickel, Cobalt, IronAbstract
Schiff bases were crucial to the advancement of inorganic, bioinorganic, and optical materials as well as the creation of coordination chemistry. Most of the more frequently used types of organic compounds are Schiff bases, which are extensively utilized in inorganic, organic, and analytical chemistry. Schiff base ligands are very valuable because they can form stable metal complexes with a variety of transition and other metal ions. Schiff bases are produced when a primary amine condenses with an aldehyde or ketone. With an emphasis on structure-activity connections, the biological activity of these complexes is examined, including their antibacterial, anticancer, antioxidant, and enzyme inhibitory qualities. The review also emphasizes the therapeutic potential of these complexes, stressing their use in drug development as well as their difficulties and opportunities in medicinal chemistry. We will talk about this in this paper. Computational Understanding of Synthesized Schiff Base and Its Transition Metal Complexes' Binding Affinity and Drug-Likeness.
